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Small parcel items ship regular ground via delivery services such as FedEx, UPS or DHL. Orders typically take 2-3 business days to process and in-stock items will usually be delivered 3-5 days from the date that they ship (depending on origin and destination). If there is a delay, you will be notified by email. No signature is required for standard ground shipping, so you may want to make arrangements to have packages brought inside soon after delivery, if you are unable to receive it in person.We speak a lot about the importance of gut health—not only for beauty—but also in terms of our overall health, wellbeing and immunity. But before we can fully understand why the gut is so integral to our health, it’s first essential to learn more about the physiology of the gut itself—and how it works.
Description
Artesunate, a well known derivative of artemisinin, is a potential drug for treatment of Babesia infection
Composition.Each uncoated chewable tablet contains Artesunate IP 250mg
Dosage:12 5mg/kg b. wt once daily for 10 days through oral route
Pharmacodynamics: The action of artesunate is generally thought to depend upon activation involving iron-mediated cleavage of the endoperoxide bridge of DHA to generate an unstable organic free radical followed by alkylation, where the free radical binds to parasite proteins leading to destruction of parasite membranes
Pharmacokinetics: Artesunate is a water soluble derivative of artemisinin. It is rapidly absorbed and extensively, and almost completely hydrolysed to its active metabolite DHA before reaching the systemic circulation. The absorption of DHA after an oral dosing of artesunate, takes about an hour. The elimination half-life of artesunate is less than 3 hours and that of DHA is less than 1 hour (-45 minutes) with oral dosing of artesunate. The bioavailability of oral artesunate is up to 60%.
Indications:
ARTEBABE is indicated with combination drugs for the treatment of Relapsing Babesiosis in Dogs. The combination drugs include ARTEBABE, ATAVON-PRO & MACROZEE for treatment of Relapsing Babesiosis in Dogs and ARTEBABE, ATAVON-PRO, MACROZEE and IMIDOPET for the treatment of Tick Fever caused by mixed infection due to B. canis, B. gibsoni, E. canis, A. platys and H. canis.
Directions for Use: Use either whole tablet or split it as required for administration.
Mode of action: Artesunate acts by inhibiting heme polymerization, generating ROS, destabilizing parasite membrane, alkylating proteins and inhibiting PfATP6.
Side effects: Side effects of artesunate include vomiting, soft faeces, decreasedactivity, anorexia and splenic red pulp vacuolation The tablet may be fed by hand or placed on food. Open the animal’s mouth gently and slowly administer the tablet. Care should be taken to ensure that the dog consumes the complete dose. Coughing may be observed in some animals during and for several minutes following administration. Avoid over- or under-dosing.
Storage: Store in a cool, dry place at room temperature. Keep the medicine out of reach of children.
